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Article

Quantification of Salmonella enterica serovar Typhimurium population dynamics in murine infection using a highly diverse barcoded library.

eLife - 13 Feb 2025

Hotinger Julia A, Campbell Ian W, Hullahalli Karthik, Osaki Akina, Waldor Matthew K

Abstract excerpt

Murine models are often used to study the pathogenicity and dissemination of the enteric pathogen Salmonella enterica serovar Typhimurium. Here, we quantified S. Typhimurium population dynamics in mice using the STAMPR analytic pipeline and a highly diverse S. Typhimurium barcoded library containing ~55,000 unique strains distinguishable by genomic barcodes by enumerating S. Typhimurium founding populations and...

Read the complete abstract on PubMed

Topics

Salmonella enterica
Serogroup
Salmonella Infections, Animal
Animals
DNA Barcoding, Taxonomic
Gene Library

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Variation

Streptomycin

Intestines

Bile

Gallbladder

Male

Female

Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 39945742
DOI: 10.7554/eLife.101388
PMCID: PMC11825126

Provenance

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