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The role of PIMT in Alzheimer's disease pathogenesis: A novel hypothesis

8 May 2023

Abstract excerpt

There are multiple theories of Alzheimer's disease pathogenesis. One major theory is that oxidation of amyloid beta (Aβ) promotes plaque deposition that directly contributes to pathology. A competing theory is that hypomethylation of DNA (due to altered one carbon metabolism) results in pathology through altered gene regulation. Herein, we propose a novel hypothesis involving L-isoaspartyl methyltransferase...

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PMID: 37157118
DOI: 10.1002/alz.13115

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