Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer's Disease.

Nutrients - 10 Dec 2016

Troesch Barbara, Weber Peter, Mohajeri M Hasan

Abstract excerpt

Alzheimer's disease (AD) is the major cause of dementia and no preventive or effective treatment has been established to date. The etiology of AD is poorly understood, but genetic and environmental factors seem to play a role in its onset and progression. In particular, factors affecting the one-carbon metabolism (OCM) are thought to be important and elevated homocysteine (Hcy) levels, indicating impaired OCM,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Cystathionine beta-Synthase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evidence-Based Medicine

Share to Ferredoxin-NADP Reductase

Share to Glycine Hydroxymethyltransferase

Share to Nutrigenomics

Share to Nutritional Status

Share to Vitamin B Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 27973419
DOI: 10.3390/nu8120803
PMCID: PMC5188458

Genes

OCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer's Disease.PMID 27973419Read ↗

One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?Semantic proximity Read ↗

One-Carbon Metabolism and Alzheimers Disease: Focus on EpigeneticsSemantic proximity Read ↗

Brain B Vitamin Status and One-Carbon Metabolism Gene Polymorphisms are Associated with Cognitive Impairment in Alzheimer’s and Parkinson’s DiseaseSemantic proximity Read ↗

Abnormal Homocysteine Metabolism: An Insight of Alzheimer’s Disease from DNA MethylationSemantic proximity Read ↗

Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls.Semantic proximity Read ↗

Associations among dietary 1-carbon metabolism nutrients, genetic risk, and Alzheimer disease: a prospective cohort study.Semantic proximity Read ↗

One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus.Semantic proximity Read ↗

Homocysteine Thiolactone Detoxifying Enzymes and Alzheimer’s DiseaseSemantic proximity Read ↗

Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFRSemantic proximity Read ↗

The role of one-carbon metabolism in health and disease : a genetic epidemiology perspectiveSemantic proximity Read ↗

Methylenetetrahydrofolate reductase gene and risk of Alzheimer's disease in Koreans.Semantic proximity Read ↗

The role of PIMT in Alzheimer's disease pathogenesis: A novel hypothesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.