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Article

ESMpHLA: Evolutionary Scale Model-Based Deep Learning Prediction of HLA Class I Binding Peptides.

HLA - 1 May 2025

Cheng Xiaorui, Mei Hu, Chen Pengji, Wu Haixia, Liu Rui, Lei Yuanyuan, Wang Pingqing

Abstract excerpt

The recognition of endogenous peptides by HLA class I plays a crucial role in CD8+ T cell immune responses and human adaptive cell immune. Thus, the prediction of HLA class I-peptide binding affinities is always the core issue for the research of immune recognition and vaccine development. In this study, an evolutionary scale model (ESM) combined with parallel CNN blocks and a cross attention mechanism was used...

Read the complete abstract on PubMed

Topics

Humans
Deep Learning
Alleles
Peptides
Protein Binding
Histocompatibility Antigens Class I
HLA-A Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HLA-B Antigens

HLA-C Antigens

Computational Biology

ROC Curve

Source

Identifiers

PMID: 40405507
DOI: 10.1111/tan.70263

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