Article

APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling

2023-04-29

Abstract excerpt

<h4>Background</h4> Valve remodeling is a complex process involving extracellular matrix organization, development of trilaminar structures, and physical elongation of valve leaflets. However, the cellular and molecular mechanisms regulating valve remodeling and their roles in congenital valve disorders remain poorly understood. <h4>Methods</h4> Semilunar valves and atrioventricular valves from healthy and age-m...

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Literature Corpus work: 9cf5fe04-d085-5bcf-bfb2-71372a4dc1e4
DOI: 10.1101/2023.04.26.538443

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