Article
Hesr2 knockout mice develop aortic valve disease with advancing age.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2013
Kokubo Hiroki, Miyagawa-Tomita Sachiko, Nakashima Yasumi, Kume Tsutomu, Yoshizumi Masao, Nakanishi Toshio, Saga Yumiko
Abstract excerpt
OBJECTIVE: Acquired heart diseases, such as valve disease, are major causes of human morbidity and mortality. However, the pathological mechanisms underlying these diseases are largely unknown. Our aim is to identify the role of the hairy and enhancer of split-related (Hesr)-2 gene in the adult heart. METHODS AND RESULTS: Echocardiography detected heart dysfunctions indicative of aortic valve anomalies, stenosis,...
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