Article

Targeting Osteosarcoma heterogeneity to improve therapeutic response

2025-01-03

Abstract excerpt

<h4>Summary</h4> Intra tumor heterogeneity complicates cancer therapy by providing tumors with the ability to alter their phenotypes and become more therapy resistant. Here, we tested the hypothesis that identifying and modulating expression of key state-specific transcription factors could be used as a strategy for driving cells to a more therapy-sensitive state. Recent single-cell studies have explored the inte...

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Literature Corpus work: 9cd671d2-d963-57b7-9e51-40448d6b632c
DOI: 10.1101/2025.01.02.631118

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