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Article

Single-Cell Spatial–Temporal Analysis ofZNF451in Mediating Drug Resistance and CD8+T Cell Dysfunction

1 Jan 2024

Abstract excerpt

Cisplatin is widely used to treat osteosarcoma, but recurrent cases often develop resistance, allowing the disease to progress and complicating clinical management. This study aimed to elucidate the immune microenvironment of osteosarcoma, providing insights into the mechanisms of recurrence and identifying potential therapeutic strategies. By analyzing multiple single-cell and bulk RNA-sequencing datasets, we...

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PMID: 39534688
DOI: 10.34133/research.0530

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