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Article

Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS.

PloS one - 1 Jan 2015

Rabinovich-Toidman Polina, Rabinovich-Nikitin Inna, Ezra Assaf, Barbiro Beka, Fogel Hilla, Slutsky Inna, Solomon Beka

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease and it is the most common adult onset neurodegenerative disorder affecting motor neurons. There is currently no effective treatment for ALS and our understanding of the pathological mechanism is still far away from prevention and/or treatment of this devastating disease. Amyloid precursor protein (APP) is a transmembrane protein that...

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Source

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Identifiers

PMID: 26600047
DOI: 10.1371/journal.pone.0143420
PMCID: PMC4658003

Genes

APP
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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