Article

Lynronne antimicrobial peptides with terminal D amino acid enantiomers synergize with bedaquiline against Mycobacterium tuberculosis

2024-09-16

Abstract excerpt

<title>Abstract</title> Tuberculosis (TB) treatment is challenging due to prolonged chemotherapy and rising multidrug resistance. Here, we investigated the antimicrobial properties of the antimicrobial peptides (AMPs) lynronne (LYN)-1, -2 and -3, both in their natural form or with terminal D-enantiomers, alongside their synergistic effects with common TB drugs. Notably, D-enantiomer replacement improves LYNs’...

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Literature Corpus work: 5fca9114-e271-50f7-856a-f5a54fd8b408
DOI: 10.21203/rs.3.rs-4642869/v1

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