An Ifnar1 allele impairs the colonization of gut bacteria and promotes tuberculosis

Abstract excerpt

<title>Abstract</title> <p>Both host genetics and gut microbiome have important effects on human health, yet how host genetics regulates gut bacteria and further determines disease susceptibility remains unclear. Here, we find that gut microbiome pattern of active tuberculosis (TB) patients is characterized by a reduction of core species found across healthy controls, particularly <italic>Akkermansia muciniphila<...

Topics

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• Anti-Bacterial Agents
• Clostridium difficile and Clostridium perfringens research
• Gastrointestinal Microbiome
• Gut microbiota and health
• Mice
• Mice, Inbred C57BL
• Mutation
• Obesity

Identifiers and source

Literature Corpus work

989d03f3-5158-57e3-b8ef-49f8e3be87cb

DOI

10.21203/rs.3.rs-847439/v1