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Article

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action.

Science translational medicine - 26 Oct 2016

Pommier Yves, O'Connor Mark J, de Bono Johann

Abstract excerpt

Poly(ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism of action by PARP "trapping" and what this means for both clinical monotherapy and combination with chemotherapeutic agents.

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Identifiers

PMID: 27797957
DOI: 10.1126/scitranslmed.aaf9246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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