Article

Complement C5 is Not Critical for the Formation of Sub-RPE Deposits in Efemp1 Mutant Mice

2021-02-01

Abstract excerpt

The complement system plays a role in the formation of sub-retinal pigment epithelial (RPE) deposits in early stages of age-related macular degeneration (AMD). But the specific mechanisms that connect complement activation and deposit formation in AMD patients are unknown, which limits the development of efficient therapies to reduce or stop disease progression. We have previously demonstrated that C3 blockage pre...

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Literature Corpus work: 81114e45-656c-507e-a42b-e0ee2e97fcdd
DOI: 10.21203/rs.3.rs-154013/v1

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