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Article

Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice.

Scientific reports - 17 May 2021

Garland Donita L, Pierce Eric A, Fernandez-Godino Rosario

Abstract excerpt

The complement system plays a role in the formation of sub-retinal pigment epithelial (RPE) deposits in early stages of age-related macular degeneration (AMD). But the specific mechanisms that connect complement activation and deposit formation in AMD patients are unknown, which limits the development of efficient therapies to reduce or stop disease progression. We have previously demonstrated that C3 blockage...

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Identifiers

PMID: 34001980
DOI: 10.1038/s41598-021-89978-8
PMCID: PMC8128922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice.PMID 34001980Read ↗

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