Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A local complement response by RPE causes early-stage macular degeneration.

Human molecular genetics - 1 Oct 2015

Fernandez-Godino Rosario, Garland Donita L, Pierce Eric A

Abstract excerpt

Inherited and age-related macular degenerations (AMDs) are important causes of vision loss. An early hallmark of these disorders is the formation of sub-retinal pigment epithelium (RPE) basal deposits. A role for the complement system in MDs was suggested by genetic association studies, but direct functional connections between alterations in the complement system and the pathogenesis of MD remain to be defined....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Disease Models, Animal
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Macular Degeneration

Share to Matrix Metalloproteinases

Share to Retinal Pigment Epithelium

Source

Open in PubMed Open full text

Identifiers

PMID: 26199322
DOI: 10.1093/hmg/ddv287
PMCID: PMC4572070

Genes

RPE
EFEMP1
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A local complement response by RPE causes early-stage macular degeneration.PMID 26199322Read ↗

Complement C5 is Not Critical for the Formation of Sub-RPE Deposits in Efemp1 Mutant MiceSemantic proximity Read ↗

Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice.Semantic proximity Read ↗

Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway.Semantic proximity Read ↗

Complement C5 is not critical for the formation of sub-RPE deposits in <i>Efemp1</i> mutant miceSemantic proximity Read ↗

Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathwaySemantic proximity Read ↗

Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degenerationSemantic proximity Read ↗

The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in miceSemantic proximity Read ↗

Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degenerationSemantic proximity Read ↗

Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-Related Macular Degeneration and Potential Therapies.Semantic proximity Read ↗

Complement C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosaSemantic proximity Read ↗

As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting TissuesSemantic proximity Read ↗

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.