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Bioprinted 3D Outer Retina Barrier Uncovers RPE-dependent Choroidal Phenotype in Advanced Macular Degeneration

2021-01-13

Abstract excerpt

<title>Abstract</title> <p>Age-related macular degeneration (AMD), a leading cause of blindness, initiates in the outer-blood-retina-barrier (oBRB) formed by Retinal pigment epithelium (RPE), Bruch’s membrane, and choriocapillaris. The mechanism of AMD initiation and progression remain poorly understood due to the lack of physiologically relevant oBRB models. We engineered a native-like 3D-oBRB tissue by bioprint...

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Literature Corpus work
9b8b8124-e6f2-546d-8f91-485514931e02
DOI
10.21203/rs.3.rs-135775/v1
Open publication

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Bioprinted 3D Outer Retina Barrier Uncovers RPE-dependent Choroidal Phenotype in Advanced Macular DegenerationDOI 10.21203/rs.3.rs-135775/v1
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