Article

Epigenome-wide Association Study of Psilocybin-Induced Methylome Changes in Alcohol Use Disorder

2025-07-18

Abstract excerpt

The serotonergic hallucinogen psilocybin has shown potential as a treatment for psychiatric conditions like alcohol use disorder (AUD) and depression in clinical studies. Epigenetic mechanisms, including DNA methylation, are hypothesized to contribute to its lasting therapeutic benefits. In this exploratory study, we present the first methylome-wide analysis of psilocybin-induced changes in a cohort of detoxified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e001d34-172c-5cfe-b67f-50d0a200273f
DOI: 10.1101/2025.07.18.664368

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenome-wide Association Study of Psilocybin-Induced Methylome Changes in Alcohol Use DisorderDOI 10.1101/2025.07.18.664368Read

Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorderSemantic proximity Read

Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortexSemantic proximity Read

Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics studySemantic proximity Read

Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top targetSemantic proximity Read

Brain-epigenome wide association study (BEWAS) on the effects of two emerging psychedelics: ketamine & MDMASemantic proximity Read

Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorderSemantic proximity Read

Genetic Contributions to Alcohol Use Disorder Treatment Outcomes: A Genome-wide Pharmacogenomics StudySemantic proximity Read

Psilocybin Promotes Cell-Type-Specific Changes in the Orbitofrontal Cortex Revealed by Single-Nucleus RNA-seqSemantic proximity Read

Profiling Neuronal Methylome and Hydroxymethylome of Opioid Use Disorder in the Human Orbitofrontal CortexSemantic proximity Read

Dual methylation and hydroxymethylation study of alcohol use disorderSemantic proximity Read

A DNA methylation biomarker of alcohol consumptionSemantic proximity Read

The DNA methylation enzymatic machinery in substance use disorders: a systematic reviewSemantic proximity Read