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Article

An RNA-seq study of the mPFC of rats with different addiction phenotypes.

Brain research bulletin - 1 Dec 2022

McFalls Ashley J, Imperio Ceasar G, Woodward Emma, Krikorian Claire, Stoltsfus Brooke, Wronowski Benjamin, Grigson Patricia S, Freeman Willard M, Vrana Kent E

Abstract excerpt

Addiction is a disease of brain-reward circuitry whereby attention, motivation, memory and emotional systems become enslaved to the goal of seeking and acquiring drug, instead of responding to the natural rewards for which these systems evolved. At the intersection of reward/limbic structures, the medial prefrontal cortex (mPFC) receives and consolidates signals regarding environment and orchestrates the most...

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Identifiers

PMID: 36223840
DOI: 10.1016/j.brainresbull.2022.09.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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