Whole genome sequencing and inheritance-based variant filtering as a tool for unraveling missing heritability in pediatric cancer.

Abstract excerpt

Survival rates for pediatric cancer have significantly increased the past decades, now exceeding 70-80% for most cancer types. The cause of cancer in children and adolescents remains largely unknown and a genetic susceptibility is considered in up to 10% of the cases, but most likely this is an underestimation. Families with multiple pediatric cancer patients are rare and strongly suggestive for an underlying...

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