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Article

Selection criteria for assembling a pediatric cancer predisposition syndrome gene panel.

Familial cancer - 1 Oct 2021

Byrjalsen Anna, Diets Illja J, Bakhuizen Jette, Hansen Thomas van Overeem, Schmiegelow Kjeld, Gerdes Anne-Marie, Stoltze Ulrik, Kuiper Roland P, Merks Johannes H M, Wadt Karin, Jongmans Marjolijn

Abstract excerpt

Increasing use of genomic sequencing enables standardized screening of all childhood cancer predisposition syndromes (CPS) in children with cancer. Gene panels currently used often include adult-onset CPS genes and genes without substantial evidence linking them to cancer predisposition. We have developed criteria to select genes relevant for childhood-onset CPS and assembled a gene panel for use in children with...

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Source

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Identifiers

PMID: 34061292
DOI: 10.1007/s10689-021-00254-0
PMCID: PMC8484084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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