Article

Defective engram allocation contributes to impaired fear memory performance in Down syndrome

2023-01-11

Abstract excerpt

Down syndrome (DS) is the most common genetic form of intellectual disability (ID). The cellular and molecular mechanisms contributing to ID in DS are not completely understood. Recent evidence indicates that a given memory is encoded by sparsely distributed neurons, highly activated during learning, the engram cells. Intriguingly, mechanisms that are of paramount importance for engram formation are impaired in DS...

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Literature Corpus work: 9c957e0b-2a27-5d4d-bdba-4a5341438e39
DOI: 10.1101/2023.01.11.523460

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