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Article

Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndrome

1 Mar 2021

Abstract excerpt

Abstract Down syndrome (DS) is a genetic trisomic disorder that produces life-long changes in physiology and cognition. Many of the changes in learning and memory seen in DS are reminiscent of disorders involving the hippocampal/entorhinal circuit. Mouse models of DS typically involve trisomy of murine chromosome 16 is homologous for many of the genes triplicated in human trisomy 21, and provide us with good...

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PMID: 33763235
DOI: 10.1042/ns20200011

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