Article
Morphological alterations in the hippocampus of the Ts65Dn mouse model for Down Syndrome correlate with structural plasticity markers.
Histology and histopathology - 1 Jan 2018
Villarroya Olga, Ballestín Raúl, López-Hidalgo Rosa, Mulet Maria, Blasco-Ibáñez José Miguel, Crespo Carlos, Nacher Juan, Gilabert-Juan Javier, Varea Emilio
Abstract excerpt
Down syndrome (DS) is the most common chromosomal aneuploidy. Although trisomy on chromosome 21 can display variable phenotypes, there is a common feature among all DS individuals: the presence of intellectual disability. This condition is partially attributed to abnormalities found in the hippocampus of individuals with DS and in the murine model for DS, Ts65Dn. To check if all hippocampal areas were equally...
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