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Article

Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.

American journal of physiology. Heart and circulatory physiology - 15 Nov 2012

Dolmatova Elena, Spagnol Gaelle, Boassa Daniela, Baum Jennifer R, Keith Kimberly, Ambrosi Cinzia, Kontaridis Maria I, Sorgen Paul L, Sosinsky Gina E, Duffy Heather S

Abstract excerpt

Fibrosis following myocardial infarction is associated with increases in arrhythmias and sudden cardiac death. Initial steps in the development of fibrosis are not clear; however, it is likely that cardiac fibroblasts play an important role. In immune cells, ATP release from pannexin 1 (Panx1) channels acts as a paracrine signal initiating activation of innate immunity. ATP has been shown in noncardiac systems to...

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Identifiers

PMID: 22982782
DOI: 10.1152/ajpheart.00251.2012
PMCID: PMC3517637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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