Noninvasive enrichment of circulating tumor biomarkers in a mouse model of diffuse midline glioma using focused ultrasound

Abstract excerpt

<h4>Background</h4> Diagnosing diffuse midline glioma (DMG) through invasive tissue biopsies is challenging due to the tumor’s eloquent location at the pons. Liquid biopsies offer a promising noninvasive alternative; however, their limited detection sensitivity and lack of information on the source of biomarkers pose great challenges. This study aimed to evaluate the feasibility and safety of using focused ultras...

Topics

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• Activin Receptors, Type I
• Biomarkers, Tumor
• Brain Neoplasms
• Brain Stem Neoplasms
• Circulating Tumor DNA
• DNA Copy Number Variations
• Liquid Biopsy
• Mutation

Identifiers and source

Literature Corpus work

9c67094b-60f8-5fef-bf5d-a0d3322dfcac

DOI

10.64898/2025.12.02.691913