Article

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

2022-06-17

Abstract excerpt

Chromosomal instability (CIN), the inability to correctly segregate chromosomes during cell division, is a common characteristic of solid tumors. CIN contributes to tumor evolution by promoting intratumor heterogeneity, thus facilitating resistance to cancer therapies. In vitro studies have demonstrated that cells with complex karyotypes are recognized and eliminated by natural killer (NK) cells. Paradoxically, i...

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Literature Corpus work: 45ebf40e-8b39-5fcf-a6a9-add5f1e31c94
DOI: 10.1101/2022.06.16.496429

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