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The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology

1 Oct 2018

Abstract excerpt

Early-phase pathologies of Alzheimer's disease (AD) are attracting much attention after clinical trials of drugs designed to remove beta-amyloid (Aβ) aggregates failed to recover memory and cognitive function in symptomatic AD patients. Here, we show that phosphorylation of serine/arginine repetitive matrix 2 (SRRM2) at Ser1068, which is observed in the brains of early phase AD mouse models and postmortem...

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PMID: 30283027
DOI: 10.1038/s41380-018-0253-8

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