Article

Decoding Early Parkinson's: A Network-Based Approach to Drug Target Identification

2024-10-04

Abstract excerpt

<title>Abstract</title> <p>Despite the abundance of large-scale molecular and drug-response data, current research on early-onset Parkinson's Disease (EOPD) markers often lacks mechanistic interpretation of drug-gene relationships. This limits our understanding of how drugs exert their therapeutic effects. While existing studies provide valuable EOPD markers, the mechanisms by which targeted drugs act remain poor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c3f4ae3-59a9-504c-bf3a-20c645fecc36
DOI: 10.21203/rs.3.rs-5018761/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding Early Parkinson's: A Network-Based Approach to Drug Target IdentificationDOI 10.21203/rs.3.rs-5018761/v1Read

Constructing Parkinson's disease progression- endotype molecular networks for drug repurposing: multi-omics evidence aggregation and large-scale real-world data validationSemantic proximity Read

Phenome-based gene discovery provides information about Parkinson's disease drug targets.Semantic proximity Read

A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s diseaseSemantic proximity Read

Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal dataSemantic proximity Read

Network medicine informed multi-omics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral SclerosisSemantic proximity Read

From Neural Connectopathy to a Therapeutic Path: An Integrated Multi-omics Framework Identifies a Causal Gene and Drug Candidates for Parkinson's Disease with mild cognitive impairmentSemantic proximity Read

Plasma Proteomics for Parkinson’s Disease: Diagnostic Classification, Severity Association, and Therapeutic HypothesesSemantic proximity Read

RETRACTED: A systematic genomic screen of 755 early-onset Parkinson’s patients from the 100,000 Genomes Project increases diagnostic yield and directs clinical pathwaysSemantic proximity Read

A Hybrid Machine Learning And Network Analysis Approach Reveals Two Parkinson's Disease Subtypes From 115 RNA-Seq Post-mortem Brain SamplesSemantic proximity Read

Network medicine informed multi-omics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral SclerosisSemantic proximity Read

A network medicine framework for multi-modal data integration in therapeutic target discoverySemantic proximity Read

Identification of Parkinson PACE subtypes and repurposing treatments through integrative analyses of multimodal clinical progression, neuroimaging, genetic, and transcriptomic dataSemantic proximity Read