Phenome-based gene discovery provides information about Parkinson's disease drug targets.

Abstract excerpt

BACKGROUND: Parkinson disease (PD) is a severe neurodegenerative disease without curative drugs. The highly complex and heterogeneous disease mechanisms are still unclear. Detecting novel PD associated genes not only contributes in revealing the disease pathogenesis, but also facilitates discovering new targets for drugs. METHODS: We propose a phenome-based gene prediction strategy to identify disease-associated...

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