Article

A network medicine framework for multi-modal data integration in therapeutic target discovery

2025-06-01

Abstract excerpt

The high cost and attrition rate of drug development underscore the need for more effective strategies for therapeutic target discovery. Here, we present a network medicine-based machine learning framework that integrates single-cell transcriptomics, bulk multi-omic profiles, genome-wide CRISPR perturbation screens, and protein-protein interaction networks to systematically prioritise disease-specific targets. App...

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Literature Corpus work: 1eaffc1d-b9b3-54f6-b6d8-0ae5e6c4a717
DOI: 10.1101/2025.05.29.656813

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