Article

Multi-Scale Sequence Encoding Distinguishes Long-Lived and Short-Lived Proteins Revealed by Protein Language Model Embeddings

2026-05-07

Abstract excerpt

<title>Abstract</title> <p>Protein stability and turnover are fundamental determinants of proteome regulation, yet how protein lifetime is specified by amino-acid sequences remains incompletely understood. Here, we identify a previously uncharacterized, multi-scale organization of sequence features associated with protein stability using protein language model (PLM) representations. Using experimentally derived h...

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Literature Corpus work: 9c343b5d-06f1-50d2-9489-2acd4649d4c0
DOI: 10.21203/rs.3.rs-9298535/v1

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Multi-Scale Sequence Encoding Distinguishes Long-Lived and Short-Lived Proteins Revealed by Protein Language Model EmbeddingsDOI 10.21203/rs.3.rs-9298535/v1Read

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