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Amino acid sequence encodes protein abundance shaped by protein stability at reduced synthesis cost.

Protein science : a publication of the Protein Society - 1 Jan 2025

Buric Filip, Viknander Sandra, Fu Xiaozhi, Lemke Oliver, Carmona Oriol Gracia, Zrimec Jan, Szyrwiel Lukasz, Mülleder Michael, Ralser Markus, Zelezniak Aleksej

Abstract excerpt

Understanding what drives protein abundance is essential to biology, medicine, and biotechnology. Driven by evolutionary selection, an amino acid sequence is tailored to meet the required abundance of a proteome, underscoring the intricate relationship between sequence and functional demand. Yet, the specific role of amino acid sequences in determining proteome abundance remains elusive. Here we show that the...

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Identifiers

PMID: 39665261
DOI: 10.1002/pro.5239
PMCID: PMC11635393

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