Article
Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing
2019-10-08
Abstract excerpt
Any replicating system in which heritable variants with differing replicative potentials can arise is subject to a Darwinian evolutionary process. The continually replicating adult tissue stem cells that control the integrity of many tissues of long-lived, multicellular, complex vertebrate organisms, including humans, constitute such a replicating system. Our suggestion is that somatic selection for mutations (or...
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Identifiers and source
- Literature Corpus work
- 9c3271c7-d568-55ef-b85a-c809f106643f
- DOI
- 10.1101/797530