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Article

Aging is an adaptation that selects in animals against disruption of homeostasis.

Medical hypotheses - 1 Oct 2018

Muller Anthonie W J

Abstract excerpt

During evolution, Muller's ratchet permanently generates deleterious germline mutations that eventually must be defused by selection. It seems widely held that cancer and aging-related diseases (ARDs) cannot contribute to this germline gene selection because they tail reproduction and thus occur too late, at the end of the life cycle. Here we posit however that by lessening the offspring's survival by proxy...

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Source

Identifiers

PMID: 30122495
DOI: 10.1016/j.mehy.2018.07.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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