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Cancer stem cells as ‘units of selection’

23 Oct 2012

Abstract excerpt

Cancer development is widely recognized to be a somatic cell evolutionary process with complex dynamics and highly variable time frames. Variant cells and descendent subclones gain competitive advantage via their fitness in relation to micro-environmental selective pressures. In this context, the 'unit' of selection is the cell, but not any cell. The so-called 'cancer stem cells' have the essential properties...

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PMID: 23396760
DOI: 10.1111/eva.12017

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