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Article

Tissue mosaicism following stem cell aging: blood as an exemplar.

Nature aging - 1 Mar 2024

Kapadia Chiraag D, Goodell Margaret A

Abstract excerpt

Loss of stem cell regenerative potential underlies aging of all tissues. Somatic mosaicism, the emergence of cellular patchworks within tissues, increases with age and has been observed in every organ yet examined. In the hematopoietic system, as in most tissues, stem cell aging through a variety of mechanisms occurs in lockstep with the emergence of somatic mosaicism. Here, we draw on insights from aging...

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Identifiers

PMID: 38438628
DOI: 10.1038/s43587-024-00589-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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