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Article

Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition

21 Apr 2020

Abstract excerpt

The etiology of Parkinson's disease is largely unknown. Genome-wide transcriptomic studies in bulk brain tissue have identified several molecular signatures associated with the disease. While these studies have the potential to shed light into the pathogenesis of Parkinson's disease, they are also limited by two major confounders: RNA post-mortem degradation and heterogeneous cell type composition of bulk tissue...

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PMID: 32317022
DOI: 10.1186/s40478-020-00932-7

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