Article

sigNATURE maps cohort-specific T-cell states to reproducible programs of ICI response

2026-04-15

Abstract excerpt

Immune checkpoint inhibitors (ICIs) can induce durable responses across cancers, yet T-cell biomarkers of response remain difficult to reproduce across single-cell RNA-seq studies. A major reason is that T-cell states are typically defined de novo within each cohort, making reported marker genes sensitive to cohort composition and analytic choices rather than stable cellular programs. Here we present sigNATURE (si...

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Literature Corpus work: 9bfabcc6-4e68-5346-b16c-acb227bd6eb8
DOI: 10.64898/2026.04.14.718532

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