Article

A yeast model of 5-oxoproline accumulation reveals a general toleration to 5-oxoproline

2025-12-23

Abstract excerpt

5-oxoproline (5-OP) or pyroglutamic acid is an intermediate of the degradation arc of the glutathione cycle. It is metabolized into glutamate through the action of the 5-oxoprolinase enzyme, the only enzyme known to act on this metabolite. 5-OP has long been known to be relatively inert with a proposed role as an osomoprotectant. Recent studies on the 5-oxoprolinase enzyme in mammalian cells have, however, shown t...

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Literature Corpus work: 9bf9523f-40de-5b67-bc8e-5f32c12da5e8
DOI: 10.64898/2025.12.21.695865

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