Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight.

doi:10.1074/jbc.M117.805028

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Article

Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight.

The Journal of biological chemistry - 29 Sept 2017

Niehaus Thomas D, Elbadawi-Sidhu Mona, de Crécy-Lagard Valérie, Fiehn Oliver, Hanson Andrew D

Abstract excerpt

5-Oxoproline (OP) is well-known as an enzymatic intermediate in the eukaryotic γ-glutamyl cycle, but it is also an unavoidable damage product formed spontaneously from glutamine and other sources. Eukaryotes metabolize OP via an ATP-dependent 5-oxoprolinase; most prokaryotes lack homologs of this enzyme (and the γ-glutamyl cycle) but are predicted to have some way to dispose of OP if its spontaneous formation in...

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PMID: 28830929
DOI: 10.1074/jbc.M117.805028
PMCID: PMC5625064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.