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Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae.

Scientific reports - 22 Sept 2017

Ohashi Kazuto, Chaleckis Romanas, Takaine Masak, Wheelock Craig E, Yoshida Satoshi

Abstract excerpt

Kynurenic acid (KA) is a tryptophan (Trp) metabolite that is synthesised in a branch of kynurenine (KYN) pathway. KYN aminotransferase (KAT) catalyses deamination of KYN, yielding KA. Although KA synthesis is evolutionarily conserved from bacteria to humans, the cellular benefits of synthesising KA are unclear. In this study, we constructed a KAT-null yeast mutant defective in KA synthesis to clarify the cellular...

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Identifiers

PMID: 28939805
DOI: 10.1038/s41598-017-12392-6
PMCID: PMC5610271

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Source receipt: pubmed, retrieved 7 Sept 2026.

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