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Article

Oxidative stress, metabolomics profiling, and mechanism of local anesthetic induced cell death in yeast

3 Feb 2017

Abstract excerpt

The World Health Organization designates lidocaine as an essential medicine in healthcare, greatly increasing the probability of human exposure. Its use has been associated with ROS generation and neurotoxicity. Physiological and metabolomic alterations, and genetics leading to the clinically observed adverse effects have not been temporally characterized. To study alterations that may lead to these undesirable...

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PMID: 28236766
DOI: 10.1016/j.redox.2017.01.025

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