Prolonged treatment with mevalonolactone induces oxidative stress response with reactive oxygen species production, mitochondrial depolarization and inflammation in human glioblastoma U-87 MG cells.

Abstract excerpt

Mevalonate pathway impairment has been observed in diverse diseases, including Mevalonate Kinase Deficiency (MKD). MKD is a hereditary auto-inflammatory disorder, due to mutations at mevalonate kinase gene (MVK), encoding mevalonate kinase (MK) enzyme. To date, the most accredited MKD pathogenic hypothesis suggests that the typical MKD phenotypes might be due to a decreased isoprenoid production rather than to...

Topics

• Glioblastoma
• Humans
• Inflammation
• Mevalonate Kinase Deficiency
• Mevalonic Acid
• Oxidative Stress
• Phenotype
• Phosphotransferases (Alcohol Group Acceptor)
• Reactive Oxygen Species