Article

Sphingosine kinase 2 suppresses neutrophil responses to promote viral persistence while attenuating immune pathology

2025-09-14

Abstract excerpt

Chronic virus infections often suppress immune cell functions which helps in restricting immune pathology but leads to viral persistence. However, the underlying mechanisms are incompletely understood. We recently found that sphingosine kinase 2 (SphK2)-deficient ( Sphk2 -/- ) mice succumbed to lymphocytic choriomeningitis virus (LCMV) infection due to immune pathology. In addition to heightened T cell immunity,...

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Literature Corpus work: 9bda76e9-a6d1-526d-ae9e-195ef2ba09fe
DOI: 10.1101/2025.09.08.674905

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