Article

Sphingosine 1-phosphate lyase expressed in pulmonary epithelial cells potentiates host innate defenses and alleviates influenza pathogenicity in mice

2026-07-05

Abstract excerpt

Influenza viruses circulate in humans, causing a substantial burden on global health. Investigation of influenza-host interactions could identify host factors that regulate influenza pathogenicity. Sphingosine 1-phosphate (S1P) is a bioactive lipid mediator and regulates crucial cellular processes. S1P lyase (SPL), an enzyme that mediates S1P degradation, was shown to display anti-influenza activity in a cell cult...

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Literature Corpus work: fe324136-a101-5848-a0a2-e8af4f7b4142
DOI: 10.64898/2026.07.02.736172

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