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Article

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Nature immunology - 1 Apr 2010

Berger Michael, Krebs Philippe, Crozat Karine, Li Xiaohong, Croker Ben A, Siggs Owen M, Popkin Daniel, Du Xin, Lawson Brian R, Theofilopoulos Argyrios N, Xia Yu, Khovananth Kevin, Moresco Eva Marie, Satoh Takashi, Takeuchi Osamu, Akira Shizuo, Beutler Bruce

Abstract excerpt

Here we describe a previously unknown form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra. Mice homozygous for this mutation showed enhanced susceptibility to bacterial and viral infection and diminished numbers of T cells and inflammatory monoc...

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Identifiers

PMID: 20190759
DOI: 10.1038/ni.1847
PMCID: PMC2861894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20190759-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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