Article

Non-canonical Oncostatin M Signaling Provides Protection during Respiratory Viral and Bacterial infections

2026-08-04

Abstract excerpt

Pneumonia remains a major global health burden, highlighting the need for host-directed therapies to complement antimicrobial treatment. Here, we identify Oncostatin M (OSM) as a critical regulator of pulmonary host responses during influenza and bacterial pneumonia. Loss of OSM shifted lung macrophages toward a pro-inflammatory phenotype during influenza infection and exacerbated lung injury during bacterial pneu...

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Literature Corpus work: 5c463daa-643c-5ab5-9a24-026561f7ece2
DOI: 10.64898/2026.07.30.741615

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