Article

Disrupting folate metabolism alters the capacity of bacteria in exponential growth to develop persisters to antibiotics

2018-05-31

Abstract excerpt

Bacteria can survive high doses of antibiotics through stochastic phenotypic diversification.We present initial evidence that folate metabolism could be involved with the formation of persisters. The aberrant expression of the folate enzyme gene fau seems to reduce the incidence of persisters to antibiotics. Folate impaired bacteria had a lower generation rate for persisters to both antibiotics ampicillin and ofl...

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Literature Corpus work: 9bcff98d-c7da-595f-8d4c-f2c80c1d4569
DOI: 10.1101/335505

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