Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success.

doi:10.1073/pnas.2014920118

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Article

Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success.

Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 2021

Huemer Markus, Mairpady Shambat Srikanth, Bergada-Pijuan Judith, Söderholm Sandra, Boumasmoud Mathilde, Vulin Clément, Gómez-Mejia Alejandro, Antelo Varela Minia, Tripathi Vishwachi, Götschi Sandra, Marques Maggio Ewerton, Hasse Barbara, Brugger Silvio D, Bumann Dirk, Schuepbach Reto A, Zinkernagel Annelies S

Abstract excerpt

Staphylococcus aureus causes invasive infections and easily acquires antibiotic resistance. Even antibiotic-susceptible S. aureus can survive antibiotic therapy and persist, requiring prolonged treatment and surgical interventions. These so-called persisters display an arrested-growth phenotype, tolerate high antibiotic concentrations, and are associated with chronic and recurrent infections. To characterize...

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PMID: 33574060
DOI: 10.1073/pnas.2014920118
PMCID: PMC7896289

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