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Article

Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2004

Provance D William, Gourley Christopher R, Silan Colleen M, Cameron L C, Shokat Kevan M, Goldenring James R, Shah Kavita, Gillespie Peter G, Mercer John A

Abstract excerpt

Selective, in situ inhibition of individual unconventional myosins is a powerful approach to determine their specific physiological functions. Here, we report the engineering of a myosin Vb mutant that still hydrolyzes ATP, yet is selectively sensitized to an N(6)-substituted ADP analog that inhi...

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Identifiers

PMID: 14766983
DOI: 10.1073/pnas.0305895101
PMCID: PMC357019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14766983-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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